There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to minimize afferent discomfort transmission and develop analgesia. Thus, medicines like clonidine that target alpha-two receptors can influence the transmission of ache. Clonidine is distributed in breast milk; caution https://www.proleviate.com/post/the-new-pain-killer-conolidine