In patients with critical limb ischemia, very long-term parenteral use of vasodilator prostaglandins may decrease soreness and aid ulcer therapeutic. Sores on the Toes, Ft, or Legs: Reduced extremity sores or wounds that don't heal properly or take a long time to recover is often a substantial indicator of PAD, https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/