Pentobarbital will decrease the extent or effect of conjugated estrogens by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. pentobarbital will decrease the level or outcome of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known. Contraindicated. Coadministration of doravirine with a solid CYP3A inducer mig... https://sodium-pentobarbital-mech69134.digitollblog.com/22234668/about-pentobarbital-sodium-and-phenytoin-sodium